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KMID : 1134820070360010032
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Journal of the Korean Society of Food Science and Nutrition
2007 Volume.36 No. 1 p.32 ~ p.42
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Immunoregulatory Effects of Saengshik on DSS?Induced Inflammatory Bowel Disease in Mouse Model System
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Lim Beong-Ou
Jeong Yong-Jun
Park Mi-Hyoun
Kim Jong-Dai
Hwang Sung-Joo
Yu Byung-Pal
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Abstract
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This study was conducted on the immunoregulatory effect of Saengshik on gut-associated lymphoid tissue with inflammatory bowel disease. Although the contents of IgA increased in mesenteric lymph node, IgE con-tent was suppressed by Saengshik. The same results were found in spleen, but IgA and IgE responses were very weak. Concentration of fecal IgA was high from the first day through the third day in Saengshik group. In DSS＋Saengshik group, concentration of IgA was high till the 2nd day and it maintained the highest level among the test groups on the 5th day. Concentration of IFN-gamma and IL-2 was the highest in the Saengshik group, but the concentration of TNF-alpha was lower in DSS＋Saengshik compared to DSS. The expressions of STAT1 in Saengshik group were high, while those of STAT6 were low. According to these findings, Saengshik exhibited effectiveness via increasing the IgA production, suppressing the IgE production, followed by inhibiting the production of IL-4 and IL-10. Saengshik also strengthened the immune system and alleviated injury in DSS-induced inflammation.
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KEYWORD
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Saengshik, inflammatory bowel desease, DSS, STAT1, STAT6, IFN-gamma, IL-4
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